7UCE

Structure of the anti-HIV-1 neutralizing antibody BG24 Fab fragment

Summary for 7UCE

Entry DOI	10.2210/pdb7uce/pdb
Descriptor	BG24 Fab light chain, BG24 Fab heavy chain, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
Functional Keywords	broadly neutralizing antibody, bnab, hiv-1, cd4 binding site, vh1-2, vrc01-class, antiviral protein, viral protein-immune system complex, viral protein/immune system
Biological source	Homo sapiens More
Total number of polymer chains	2
Total formula weight	47676.04
Authors	Barnes, C.O.,Bjorkman, P.J. (deposition date: 2022-03-16, release date: 2022-08-17, Last modification date: 2023-10-18)
Primary citation	Barnes, C.O.,Schoofs, T.,Gnanapragasam, P.N.P.,Golijanin, J.,Huey-Tubman, K.E.,Gruell, H.,Schommers, P.,Suh-Toma, N.,Lee, Y.E.,Cetrulo Lorenzi, J.C.,Piechocka-Trocha, A.,Scheid, J.F.,West Jr., A.P.,Walker, B.D.,Seaman, M.S.,Klein, F.,Nussenzweig, M.C.,Bjorkman, P.J. A naturally arising broad and potent CD4-binding site antibody with low somatic mutation. Sci Adv, 8:eabp8155-eabp8155, 2022 Cited by PubMed: 35960796 DOI: 10.1126/sciadv.abp8155 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation