7UCD

Transcription factor FosB/JunD bZIP domain covalently modified with the cysteine-targeting alpha-haloketone compound Z2159931480

7UCD の概要

• エントリーDOI: 10.2210/pdb7ucd/pdb
• 分子名称: Protein fosB, Transcription factor jun-D, 7-acetyl-4-methoxy-1-benzofuran-3(2H)-one, ... (4 entities in total)
• 機能のキーワード: fosb, jund, redox switch, redox sensor, transcription factor, dna binding protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 16604.72

構造登録者

Kumar, A.,Machius, M.C.,Rudenko, G. (登録日: 2022-03-16, 公開日: 2023-01-25, 最終更新日: 2023-10-25)

• 主引用文献: Kumar, A.,Aglyamova, G.,Yim, Y.Y.,Bailey, A.O.,Lynch, H.M.,Powell, R.T.,Nguyen, N.D.,Rosenthal, Z.,Zhao, W.N.,Li, Y.,Chen, J.,Fan, S.,Lee, H.,Russell, W.K.,Stephan, C.,Robison, A.J.,Haggarty, S.J.,Nestler, E.J.,Zhou, J.,Machius, M.,Rudenko, G.; Chemically targeting the redox switch in AP1 transcription factor Delta FOSB.; Nucleic Acids Res., 50:9548-9567, 2022; PubMed: 36039764; DOI: 10.1093/nar/gkac710

実験手法

X-RAY DIFFRACTION (3.21 Å)