7UBO
Crystal Structure of the first bromodomain of human BRDT in complex with the inhibitor CCD-956
Summary for 7UBO
Entry DOI | 10.2210/pdb7ubo/pdb |
Descriptor | Bromodomain testis-specific protein, N-[(2R)-1-(methylamino)-3-{1-[(4-methyl-2-oxo-1,2-dihydroquinolin-6-yl)acetyl]piperidin-4-yl}-1-oxopropan-2-yl]-5-phenylpyridine-2-carboxamide, DIMETHYL SULFOXIDE, ... (4 entities in total) |
Functional Keywords | inhibitor, regulator, transcription, transcription-inhibitor complex, transcription/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 54925.73 |
Authors | Ta, H.M.,Modukuri, R.K.,Yu, Z.,Tan, Z.,Matzuk, M.M.,Kim, C. (deposition date: 2022-03-15, release date: 2022-06-08, Last modification date: 2023-10-18) |
Primary citation | Modukuri, R.K.,Yu, Z.,Tan, Z.,Ta, H.M.,Ucisik, M.N.,Jin, Z.,Anglin, J.L.,Sharma, K.L.,Nyshadham, P.,Li, F.,Riehle, K.,Faver, J.C.,Duong, K.,Nagarajan, S.,Simmons, N.,Palmer, S.S.,Teng, M.,Young, D.W.,Yi, J.S.,Kim, C.,Matzuk, M.M. Discovery of potent BET bromodomain 1 stereoselective inhibitors using DNA-encoded chemical library selections. Proc.Natl.Acad.Sci.USA, 119:e2122506119-e2122506119, 2022 Cited by PubMed: 35622893DOI: 10.1073/pnas.2122506119 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.82 Å) |
Structure validation
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