7UAW

Structure of Clostridium botulinum prophage Tad1 in complex with 1''-2' gcADPR

Summary for 7UAW

• Entry DOI: 10.2210/pdb7uaw/pdb
• Descriptor: ABC transporter ATPase, (1S,3R,4R,6R,9S,11R,14R,15S,16R,18R)-4-(6-amino-9H-purin-9-yl)-9,11,15,16,18-pentahydroxy-2,5,8,10,12,17-hexaoxa-9lambda~5~,11lambda~5~-diphosphatricyclo[12.2.1.1~3,6~]octadecane-9,11-dione (3 entities in total)
• Functional Keywords: anti-thoeris, immune evasion, signal sequestration, viral protein
• Biological source: Clostridium botulinum
• Total number of polymer chains: 2
• Total formula weight: 29744.76

Authors

Lu, A.,Leavitt, A.,Yirmiya, E.,Amitai, G.,Garb, J.,Morehouse, B.R.,Hobbs, S.J.,Sorek, R.,Kranzusch, P.J. (deposition date: 2022-03-14, release date: 2022-10-05, Last modification date: 2024-04-03)

• Primary citation: Leavitt, A.,Yirmiya, E.,Amitai, G.,Lu, A.,Garb, J.,Herbst, E.,Morehouse, B.R.,Hobbs, S.J.,Antine, S.P.,Sun, Z.J.,Kranzusch, P.J.,Sorek, R.; Viruses inhibit TIR gcADPR signalling to overcome bacterial defence.; Nature, 611:326-331, 2022; PubMed: 36174646; DOI: 10.1038/s41586-022-05375-9

Experimental method

X-RAY DIFFRACTION (1.72 Å)