7U9I

Co-crystal structure of human CARM1 in complex with MT556 inhibitor

7U9I の概要

• エントリーDOI: 10.2210/pdb7u9i/pdb
• 分子名称: Histone-arginine methyltransferase CARM1, 7-[5-S-(4-{[(4-ethylpyridin-3-yl)methyl]amino}butyl)-5-thio-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine, UNKNOWN ATOM OR ION, ... (4 entities in total)
• 機能のキーワード: mtase, histone arginine methyltransferase, prmt4, carm1, sgc, structural genomics, structural genomics consortium, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 79012.21

構造登録者

Zeng, H.,Perveen, S.,Dong, A.,Hutchinson, A.,Seitova, A.,Gibson, E.,Hajian, T.,Li, Y.,Gao, Y.D.,Schneider, S.,Siliphaivanh, P.,Sloman, D.,Nicholson, B.,Fischer, C.,Hicks, J.,Vedadi, M.,Brown, P.J.,Arrowsmith, C.H.,Edwards, A.M.,Halabelian, L.,Structural Genomics Consortium (SGC) (登録日: 2022-03-10, 公開日: 2023-01-18, 最終更新日: 2023-10-25)

• 主引用文献: Zeng, H.,Perveen, S.,Dong, A.,Hutchinson, A.,Seitova, A.,Gibson, E.,Hajian, T.,Li, Y.,Gao, Y.D.,Schneider, S.,Siliphaivanh, P.,Sloman, D.,Nicholson, B.,Fischer, C.,Hicks, J.,Vedadi, M.,Brown, P.J.,Arrowsmith, C.H.,Edwards, A.M.,Halabelian, L.,Structural Genomics Consortium (SGC); Co-crystal structure of human CARM1 in complex with MT556 inhibitor; To Be Published,

実験手法

X-RAY DIFFRACTION (2 Å)