7U9D

Crystal Structure of Human Phosphatidylcholine Transfer Protein in Complex with PC(16:0/20:4)

Summary for 7U9D

Entry DOI	10.2210/pdb7u9d/pdb
Descriptor	Phosphatidylcholine transfer protein, [(2~{R})-1-hexadecanoyloxy-3-[oxidanyl-[2-(trimethyl-$l^{4}-azanyl)ethoxy]phosphoryl]oxy-propan-2-yl] (5~{Z},8~{Z},11~{Z},14~{Z})-icosa-5,8,11,14-tetraenoate, GLYCEROL, ... (4 entities in total)
Functional Keywords	phosphatidylcholine transfer protein, pc(16:0/20:4), complex, ligand, lipid binding protein
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	25746.49
Authors	Druzak, S.A. (deposition date: 2022-03-10, release date: 2023-04-12, Last modification date: 2024-04-24)
Primary citation	Druzak, S.A.,Tardelli, M.,Mays, S.G.,El Bejjani, M.,Mo, X.,Maner-Smith, K.M.,Bowen, T.,Cato, M.L.,Tillman, M.C.,Sugiyama, A.,Xie, Y.,Fu, H.,Cohen, D.E.,Ortlund, E.A. Ligand dependent interaction between PC-TP and PPAR delta mitigates diet-induced hepatic steatosis in male mice. Nat Commun, 14:2748-2748, 2023 Cited by PubMed: 37173315 DOI: 10.1038/s41467-023-38010-w PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.18 Å)

Structure validation