7U8F

Ternary complex structure of Cereblon-DDB1 bound to IKZF2(ZF2) and the molecular glue DKY709

7U8F の概要

• エントリーDOI: 10.2210/pdb7u8f/pdb
• 分子名称: Protein cereblon, DNA damage-binding protein 1, IKZF2, ... (8 entities in total)
• 機能のキーワード: molecular glue, targeted protein degradation, ligase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 288161.71

構造登録者

Ma, X.,Ornelas, E.,Clifton, M.C. (登録日: 2022-03-08, 公開日: 2023-03-08, 最終更新日: 2023-10-25)

• 主引用文献: Bonazzi, S.,d'Hennezel, E.,Beckwith, R.E.J.,Xu, L.,Fazal, A.,Magracheva, A.,Ramesh, R.,Cernijenko, A.,Antonakos, B.,Bhang, H.C.,Caro, R.G.,Cobb, J.S.,Ornelas, E.,Ma, X.,Wartchow, C.A.,Clifton, M.C.,Forseth, R.R.,Fortnam, B.H.,Lu, H.,Csibi, A.,Tullai, J.,Carbonneau, S.,Thomsen, N.M.,Larrow, J.,Chie-Leon, B.,Hainzl, D.,Gu, Y.,Lu, D.,Meyer, M.J.,Alexander, D.,Kinyamu-Akunda, J.,Sabatos-Peyton, C.A.,Dales, N.A.,Zecri, F.J.,Jain, R.K.,Shulok, J.,Wang, Y.K.,Briner, K.,Porter, J.A.,Tallarico, J.A.,Engelman, J.A.,Dranoff, G.,Bradner, J.E.,Visser, M.,Solomon, J.M.; Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy.; Cell Chem Biol, 30:235-247.e12, 2023; PubMed: 36863346; DOI: 10.1016/j.chembiol.2023.02.005

実験手法

X-RAY DIFFRACTION (3.15 Å)