7U8D

FKBP12 mutant V55G bound to Rapa*-3Z

Summary for 7U8D

• Entry DOI: 10.2210/pdb7u8d/pdb
• Descriptor: Peptidyl-prolyl cis-trans isomerase FKBP1A, (3S,5Z,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,30R,34aS)-5-(ethoxyimino)-9,27-dihydroxy-3-{(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-5,6,9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-octadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,11,28,29(4H,31H)-tetrone, GLYCEROL, ... (4 entities in total)
• Functional Keywords: immunophilin, rotamase, protein binding, isomerase-isomerase inhibitor complex, isomerase/isomerase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 25995.86

Authors

Wassarman, D.R.,Shokat, K.M. (deposition date: 2022-03-08, release date: 2022-09-21, Last modification date: 2023-10-18)

• Primary citation: Wassarman, D.R.,Bankapalli, K.,Pallanck, L.J.,Shokat, K.M.; Tissue-restricted inhibition of mTOR using chemical genetics.; Proc.Natl.Acad.Sci.USA, 119:e2204083119-e2204083119, 2022; PubMed: 36095197; DOI: 10.1073/pnas.2204083119

Experimental method

X-RAY DIFFRACTION (1.39 Å)