7U63

Crystal Structure Anti-Oxycodone Antibody HY2-A12 Fab Complexed with Oxycodone

Summary for 7U63

Entry DOI	10.2210/pdb7u63/pdb
Descriptor	HY2-A12 Fab Light Chain, HY2-A12 Fab Heavy Chain, 14-hydroxy-3-methoxy-17-methyl-5beta-4,5-epoxymorphinan-6-one, ... (4 entities in total)
Functional Keywords	mab, opioid, immune system
Biological source	Mus musculus (Mouse) More
Total number of polymer chains	6
Total formula weight	142036.56
Authors	Rodarte, J.V.,Pancera, M.P.,Weidle, C.,Rupert, P.B.,Strong, R.K. (deposition date: 2022-03-03, release date: 2023-01-11, Last modification date: 2023-10-25)
Primary citation	Rodarte, J.V.,Baehr, C.,Hicks, D.,Liban, T.L.,Weidle, C.,Rupert, P.B.,Jahan, R.,Wall, A.,McGuire, A.T.,Strong, R.K.,Runyon, S.,Pravetoni, M.,Pancera, M. Structures of drug-specific monoclonal antibodies bound to opioids and nicotine reveal a common mode of binding. Structure, 31:20-32.e5, 2023 Cited by PubMed: 36513069 DOI: 10.1016/j.str.2022.11.008 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation