7U3B

Structure of S. venezuelae GlgX bound to c-di-GMP and acarbose (pH 8.5)

7U3B の概要

• エントリーDOI: 10.2210/pdb7u3b/pdb
• 分子名称: Glycogen debranching enzyme GlgX, 4-O-(4,6-dideoxy-4-{[(1S,2S,3S,4R,5S)-2,3,4-trihydroxy-5-(hydroxymethyl)cyclohexyl]amino}-alpha-D-glucopyranosyl)-beta-D-glucopyranose, 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), ... (5 entities in total)
• 機能のキーワード: glgx, glycogen, acarbose, c-di-gmp, streptomyces, hydrolase
• 由来する生物種: Streptomyces venezuelae
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 651124.88

構造登録者

Schumacher, M.A.,Tschowri, N. (登録日: 2022-02-26, 公開日: 2022-10-05, 最終更新日: 2023-10-18)

• 主引用文献: Schumacher, M.A.,Wormann, M.E.,Henderson, M.,Salinas, R.,Latoscha, A.,Al-Bassam, M.M.,Singh, K.S.,Barclay, E.,Gunka, K.,Tschowri, N.; Allosteric regulation of glycogen breakdown by the second messenger cyclic di-GMP.; Nat Commun, 13:5834-5834, 2022; PubMed: 36192422; DOI: 10.1038/s41467-022-33537-w

実験手法

X-RAY DIFFRACTION (3.6 Å)