7U30
PRMT5:MEP50 Complexed with Cyclonucleoside Compound 1
Summary for 7U30
Entry DOI | 10.2210/pdb7u30/pdb |
Descriptor | Protein arginine N-methyltransferase 5, Methylosome protein 50, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | prmt5, inhibitor, cyclonucleoside, methyl transferase, transferase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 109461.47 |
Authors | Palte, R.L. (deposition date: 2022-02-25, release date: 2022-06-01, Last modification date: 2023-10-18) |
Primary citation | Kawamura, S.,Palte, R.L.,Kim, H.Y.,Sauri, J.,Sondey, C.,Mansueto, M.S.,Altman, M.D.,Machacek, M.R. Design and synthesis of unprecedented 9- and 10-membered cyclonucleosides with PRMT5 inhibitory activity. Bioorg.Med.Chem., 66:116820-116820, 2022 Cited by PubMed: 35594650DOI: 10.1016/j.bmc.2022.116820 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
Download full validation report