7U23
Single-chain LCDV-1 viral insulin-like peptide bound to IGF-1R ectodomain, leucine-zippered form
Summary for 7U23
Entry DOI | 10.2210/pdb7u23/pdb |
EMDB information | 26306 |
Descriptor | Insulin-like growth factor 1 receptor, single-chain LCDV-1 viral insulin-like peptide (2 entities in total) |
Functional Keywords | igf-1r ectodomain, inhibitor, viral insulin-like peptide, single-chain lcdv-1, signaling protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 231327.90 |
Authors | |
Primary citation | Moreau, F.,Kirk, N.S.,Zhang, F.,Gelfanov, V.,List, E.O.,Chrudinova, M.,Venugopal, H.,Lawrence, M.C.,Jimenez, V.,Bosch, F.,Kopchick, J.J.,DiMarchi, R.D.,Altindis, E.,Ronald Kahn, C. Interaction of a viral insulin-like peptide with the IGF-1 receptor produces a natural antagonist. Nat Commun, 13:6700-6700, 2022 Cited by PubMed: 36335114DOI: 10.1038/s41467-022-34391-6 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (4.6 Å) |
Structure validation
Download full validation report