7U22

Mycobacterium tuberculosis RNA polymerase sigma A holoenzyme open promoter complex containing UMN-7

Summary for 7U22

Entry DOI	10.2210/pdb7u22/pdb
Descriptor	DNA-directed RNA polymerase subunit alpha, MAGNESIUM ION, DNA-directed RNA polymerase subunit beta, ... (10 entities in total)
Functional Keywords	transcription, inhibitor, rifabutin, transcription initiation, tuberculosis, mtb, mycobacterium tuberculosis, mycobacterium smegmatis, antibiotic
Biological source	Mycobacterium tuberculosis More
Total number of polymer chains	8
Total formula weight	435378.85
Authors	Molodtsov, V.,Ebright, R.H. (deposition date: 2022-02-22, release date: 2022-10-19, Last modification date: 2023-10-18)
Primary citation	Lan, T.,Ganapathy, U.S.,Sharma, S.,Ahn, Y.M.,Zimmerman, M.,Molodtsov, V.,Hegde, P.,Gengenbacher, M.,Ebright, R.H.,Dartois, V.,Freundlich, J.S.,Dick, T.,Aldrich, C.C. Redesign of Rifamycin Antibiotics to Overcome ADP-Ribosylation-Mediated Resistance. Angew.Chem.Int.Ed.Engl., 61:e202211498-e202211498, 2022 Cited by PubMed: 36222275 DOI: 10.1002/anie.202211498 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.87 Å)

Structure validation