7U0O

Crystal structure of an enoyl-[acyl-carrier-protein] reductase InhA from Mycobacterium fortuitum bound to NAD and NITD-916

7U0O の概要

• エントリーDOI: 10.2210/pdb7u0o/pdb
• 分子名称: Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 6-[(4,4-dimethylcyclohexyl)methyl]-4-hydroxy-3-phenylpyridin-2(1H)-one, ... (6 entities in total)
• 機能のキーワード: inha, mycobacterium, pulmonary infection, cf, nad-depdendent enzyme, structural genomics, seattle structural genomics center for infectious disease, ssgcid, oxidoreductase
• 由来する生物種: Mycolicibacterium fortuitum
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 60880.10

構造登録者

Seattle Structural Genomics Center for Infectious Disease,Seattle Structural Genomics Center for Infectious Disease (SSGCID) (登録日: 2022-02-18, 公開日: 2023-02-22, 最終更新日: 2023-10-25)

• 主引用文献: Roquet-Baneres, F.,Alcaraz, M.,Hamela, C.,Abendroth, J.,Edwards, T.E.,Kremer, L.; In Vitro and In Vivo Efficacy of NITD-916 against Mycobacterium fortuitum.; Antimicrob.Agents Chemother., 67:e0160722-e0160722, 2023; PubMed: 36920188; DOI: 10.1128/aac.01607-22

実験手法

X-RAY DIFFRACTION (2.05 Å)