7U0M

Crystal structure of a enoyl-[acyl-carrier-protein] reductase (InhA) from Mycobacterium abscessus bound to NAD and NITD-916

7U0M の概要

• エントリーDOI: 10.2210/pdb7u0m/pdb
• 分子名称: Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 6-[(4,4-dimethylcyclohexyl)methyl]-4-hydroxy-3-phenylpyridin-2(1H)-one, ... (5 entities in total)
• 機能のキーワード: inha, mycobacterium, tuberculosis, cystic fibrosis, cf, pulmonary infections, structural genomics, seattle structural genomics center for infectious disease, ssgcid, oxidoreductase
• 由来する生物種: Mycobacteroides abscessus
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 61385.81

構造登録者

Seattle Structural Genomics Center for Infectious Disease,Seattle Structural Genomics Center for Infectious Disease (SSGCID) (登録日: 2022-02-18, 公開日: 2022-10-05, 最終更新日: 2023-10-18)

• 主引用文献: Alcaraz, M.,Roquet-Baneres, F.,Leon-Icaza, S.A.,Abendroth, J.,Boudehen, Y.M.,Cougoule, C.,Edwards, T.E.,Kremer, L.; Efficacy and Mode of Action of a Direct Inhibitor of Mycobacterium abscessus InhA.; Acs Infect Dis., 8:2171-2186, 2022; PubMed: 36107992; DOI: 10.1021/acsinfecdis.2c00314

実験手法