7TZO
The apo structure of human mTORC2 complex
Summary for 7TZO
Entry DOI | 10.2210/pdb7tzo/pdb |
EMDB information | 26213 |
Descriptor | Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8, Rapamycin-insensitive companion of mTOR, ... (4 entities in total) |
Functional Keywords | complex, signaling protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 8 |
Total formula weight | 1189814.63 |
Authors | Yu, Z.,Chen, J.,Pearce, D. (deposition date: 2022-02-16, release date: 2023-01-11, Last modification date: 2024-06-12) |
Primary citation | Yu, Z.,Chen, J.,Takagi, E.,Wang, F.,Saha, B.,Liu, X.,Joubert, L.M.,Gleason, C.E.,Jin, M.,Li, C.,Nowotny, C.,Agard, D.,Cheng, Y.,Pearce, D. Interactions between mTORC2 core subunits Rictor and mSin1 dictate selective and context-dependent phosphorylation of substrate kinases SGK1 and Akt. J.Biol.Chem., 298:102288-102288, 2022 Cited by PubMed: 35926713DOI: 10.1016/j.jbc.2022.102288 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.28 Å) |
Structure validation
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