7TZE

Structure of murine LAG3 domains 1-2

Summary for 7TZE

Entry DOI	10.2210/pdb7tze/pdb
Descriptor	Lymphocyte activation gene 3 protein, 2-acetamido-2-deoxy-beta-D-glucopyranose, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	immune checkpoint, t cell, ig-like fold, immunosuppressant
Biological source	Mus musculus (house mouse)
Total number of polymer chains	2
Total formula weight	52317.63
Authors	Ming, Q.,Tran, T.H.,Luca, V.C. (deposition date: 2022-02-15, release date: 2022-05-11, Last modification date: 2023-10-18)
Primary citation	Ming, Q.,Celias, D.P.,Wu, C.,Cole, A.R.,Singh, S.,Mason, C.,Dong, S.,Tran, T.H.,Amarasinghe, G.K.,Ruffell, B.,Luca, V.C. LAG3 ectodomain structure reveals functional interfaces for ligand and antibody recognition. Nat.Immunol., 23:1031-1041, 2022 Cited by PubMed: 35761082 DOI: 10.1038/s41590-022-01238-7 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.12 Å)

Structure validation