7TXC
HIC2 zinc finger domain in complex with the DNA binding motif-2 of the BCL11A enhancer
Summary for 7TXC
Entry DOI | 10.2210/pdb7txc/pdb |
Descriptor | DNA (5'-D(*AP*GP*AP*TP*AP*AP*TP*GP*CP*CP*AP*AP*CP*AP*GP*T)-3'), DNA (5'-D(*AP*CP*TP*GP*TP*TP*GP*GP*CP*AP*TP*TP*AP*TP*CP*T)-3'), Hypermethylated in cancer 2 protein, ... (4 entities in total) |
Functional Keywords | zinc-finger domain, gene expression, dna binding protein-dna complex, dna binding protein, dna binding protein/dna |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 23803.74 |
Authors | Horton, J.R.,Ren, R.,Cheng, X. (deposition date: 2022-02-08, release date: 2022-06-01, Last modification date: 2024-05-22) |
Primary citation | Huang, P.,Peslak, S.A.,Ren, R.,Khandros, E.,Qin, K.,Keller, C.A.,Giardine, B.,Bell, H.W.,Lan, X.,Sharma, M.,Horton, J.R.,Abdulmalik, O.,Chou, S.T.,Shi, J.,Crossley, M.,Hardison, R.C.,Cheng, X.,Blobel, G.A. HIC2 controls developmental hemoglobin switching by repressing BCL11A transcription. Nat.Genet., 54:1417-1426, 2022 Cited by PubMed: 35941187DOI: 10.1038/s41588-022-01152-6 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.04 Å) |
Structure validation
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