7TWU
Crystal structure of human phenylethanolamine N-methyltransferase (PNMT) in complex with (2S)-2-amino-4-(((5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(4-(7,8-dichloro-1,2,3,4-tetrahydroisoquinolin-4-yl)butyl)amino)butanoic acid and AdoHcy (SAH)
Summary for 7TWU
| Entry DOI | 10.2210/pdb7twu/pdb |
| Descriptor | Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, CADMIUM ION, ... (6 entities in total) |
| Functional Keywords | transition state analogue, chemical synthesis, drug design, neurodegenerative disease, pnmt, transferase |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 2 |
| Total formula weight | 66706.54 |
| Authors | Harijan, R.K.,Mahmoodi, N.,Minnow, Y.V.T.,Bonanno, J.B.,Almo, S.C.,Schramm, V.L. (deposition date: 2022-02-07, release date: 2023-02-15, Last modification date: 2023-10-25) |
| Primary citation | Mahmoodi, N.,Minnow, Y.V.T.,Harijan, R.K.,Bedard, G.T.,Schramm, V.L. Cell-Effective Transition-State Analogue of Phenylethanolamine N -Methyltransferase. Biochemistry, 62:2257-2268, 2023 Cited by PubMed: 37467463DOI: 10.1021/acs.biochem.3c00103 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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