7TV0

Crystal structure of BRD4 bromodomain 1 in complex with dual-acetylated SARS-CoV-2 E

7TV0 の概要

• エントリーDOI: 10.2210/pdb7tv0/pdb
• 分子名称: Bromodomain-containing protein 4, Envelope small membrane protein (3 entities in total)
• 機能のキーワード: brd4, bromodomain, sars-cov-2, covid, envelope protein, e protein, transcription
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 68568.89

構造登録者

Vann, K.R.,Holt, T.A.,Kutateladze, T.G. (登録日: 2022-02-03, 公開日: 2022-07-06, 最終更新日: 2023-11-15)

• 主引用文献: Vann, K.R.,Acharya, A.,Jang, S.M.,Lachance, C.,Zandian, M.,Holt, T.A.,Smith, A.L.,Pandey, K.,Durden, D.L.,El-Gamal, D.,Cote, J.,Byrareddy, S.N.,Kutateladze, T.G.; Binding of the SARS-CoV-2 envelope E protein to human BRD4 is essential for infection.; Structure, 30:1224-, 2022; PubMed: 35716662; DOI: 10.1016/j.str.2022.05.020

実験手法

X-RAY DIFFRACTION (2.6 Å)