7TSD

Structure of rat neuronal nitric oxide synthase R349A mutant heme domain in complex with 6-(3-(3,3-difluoroazetidin-1-yl)prop-1-yn-1-yl)-4-methylpyridin-2-amine

Summary for 7TSD

Entry DOI	10.2210/pdb7tsd/pdb
Descriptor	Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total)
Functional Keywords	nitric oxide synthase, inhibitor complex, heme enzyme, oxidoreductase
Biological source	Rattus norvegicus (Norway rat)
Total number of polymer chains	1
Total formula weight	49945.85
Authors	Li, H.,Poulos, T.L. (deposition date: 2022-01-31, release date: 2022-07-13, Last modification date: 2023-10-18)
Primary citation	Vasu, D.,Li, H.,Hardy, C.D.,Poulos, T.L.,Silverman, R.B. 2-Aminopyridines with a shortened amino sidechain as potent, selective, and highly permeable human neuronal nitric oxide synthase inhibitors. Bioorg.Med.Chem., 69:116878-116878, 2022 Cited by PubMed: 35772285 DOI: 10.1016/j.bmc.2022.116878 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.769 Å)

Structure validation