7TRI

Human antibody S8V1-172 in complex with the influenza hemagglutinin head domain of A/Sydney/05/1997(H3N2)

7TRI の概要

• エントリーDOI: 10.2210/pdb7tri/pdb
• 分子名称: Hemagglutinin, S8V1-172 Fab kappa light chain, S8V1-172 Fab heavy chain, ... (4 entities in total)
• 機能のキーワード: influenza, antibody, neutralizing, immune system, immune system-viral protein complex, immune system/viral protein
• 由来する生物種: Influenza A virus (A/Sydney/5/1997(H3N2)); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 82911.43

構造登録者

McCarthy, K.R. (登録日: 2022-01-28, 公開日: 2023-08-02, 最終更新日: 2024-10-30)

主引用文献

Simmons, H.C.,Watanabe, A.,Oguin Iii, T.H.,Van Itallie, E.S.,Wiehe, K.J.,Sempowski, G.D.,Kuraoka, M.,Kelsoe, G.,McCarthy, K.R.
A new class of antibodies that overcomes a steric barrier to cross-group neutralization of influenza viruses.
Plos Biol., 21:e3002415-e3002415, 2023

PubMed Abstract: Antibody titers that inhibit the influenza virus hemagglutinin (HA) from engaging its receptor are the accepted correlate of protection from infection. Many potent antibodies with broad, intra-subtype specificity bind HA at the receptor binding site (RBS). One barrier to broad H1-H3 cross-subtype neutralization is an insertion (133a) between positions 133 and 134 on the rim of the H1 HA RBS. We describe here a class of antibodies that overcomes this barrier. These genetically unrestricted antibodies are abundant in the human B cell memory compartment. Analysis of the affinities of selected members of this class for historical H1 and H3 isolates suggest that they were elicited by H3 exposure and broadened or diverted by later exposure(s) to H1 HA. RBS mutations in egg-adapted vaccine strains cause the new H1 specificity of these antibodies to depend on the egg adaptation. The results suggest that suitable immunogens might elicit 133a-independent, H1-H3 cross neutralization by RBS-directed antibodies.

PubMed: 38127922
DOI: 10.1371/journal.pbio.3002415

実験手法

X-RAY DIFFRACTION (3.6 Å)