7TQQ

Structure of human TREX1-DNA complex

Summary for 7TQQ

• Entry DOI: 10.2210/pdb7tqq/pdb
• Descriptor: Three-prime repair exonuclease 1, DNA (5'-D(P*TP*TP*GP*GP*CP*CP*GP*GP*CP*CP*AP*TP*C)-3') (3 entities in total)
• Functional Keywords: nuclease, dnase, innate immunity, autoimmunity, hydrolase, hydrolase-dna complex, hydrolase/dna
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 8
• Total formula weight: 131113.20

Authors

Zhou, W.,Richmond-Buccola, D.,Kranzusch, P.J. (deposition date: 2022-01-26, release date: 2022-08-03, Last modification date: 2023-10-18)

• Primary citation: Zhou, W.,Richmond-Buccola, D.,Wang, Q.,Kranzusch, P.J.; Structural basis of human TREX1 DNA degradation and autoimmune disease.; Nat Commun, 13:4277-4277, 2022; PubMed: 35879334; DOI: 10.1038/s41467-022-32055-z

Experimental method

X-RAY DIFFRACTION (2.2 Å)