7TNN

Complex GGNN of AMPA-subtype iGluR GluA2 in complex with auxiliary subunit gamma2 (Stargazin) at low glutamate concentration (20 uM) in the presence of cyclothiazide (100 uM)

Summary for 7TNN

Entry DOI	10.2210/pdb7tnn/pdb
EMDB information	26011 26012 26013 26014 26015 26016 26017
Descriptor	Isoform Flip of Glutamate receptor 2,Voltage-dependent calcium channel gamma-3 subunit chimera, GLUTAMIC ACID, CYCLOTHIAZIDE (3 entities in total)
Functional Keywords	ampa, iglur, stargazin, cryo-em, complex, agonist, positive allosteric modulator, subconductance level, opening, gating, glutamate, membrane protein
Biological source	Rattus norvegicus (Norway rat) More
Total number of polymer chains	4
Total formula weight	463633.46
Authors	Yelshanskaya, M.V.,Sobolevsky, A.I. (deposition date: 2022-01-21, release date: 2022-04-20, Last modification date: 2022-05-18)
Primary citation	Yelshanskaya, M.V.,Patel, D.S.,Kottke, C.M.,Kurnikova, M.G.,Sobolevsky, A.I. Opening of glutamate receptor channel to subconductance levels. Nature, 605:172-178, 2022 Cited by PubMed: 35444281 DOI: 10.1038/s41586-022-04637-w PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.91 Å)

Structure validation