7TNH
Crystal structure of CSF1R kinase domain in complex with DP-6233
Summary for 7TNH
Entry DOI | 10.2210/pdb7tnh/pdb |
Descriptor | Macrophage colony-stimulating factor 1 receptor,Fibroblast growth factor receptor 1 chimera, SODIUM ION, CHLORIDE ION, ... (5 entities in total) |
Functional Keywords | human csr1r kinase, cancer, transferase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 1 |
Total formula weight | 39083.07 |
Authors | Edwards, T.E.,Arakaki, T.L.,Chun, L.,Flynn, D.L. (deposition date: 2022-01-21, release date: 2022-08-24, Last modification date: 2023-10-18) |
Primary citation | Caldwell, T.M.,Kaufman, M.D.,Wise, S.C.,Mi Ahn, Y.,Hood, M.M.,Lu, W.P.,Patt, W.C.,Samarakoon, T.,Vogeti, L.,Vogeti, S.,Yates, K.M.,Bulfer, S.L.,Le Bourdonnec, B.,Smith, B.D.,Flynn, D.L. Discovery of acyl ureas as highly selective small molecule CSF1R kinase inhibitors. Bioorg.Med.Chem.Lett., 74:128929-128929, 2022 Cited by PubMed: 35961461DOI: 10.1016/j.bmcl.2022.128929 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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