7TNH

Crystal structure of CSF1R kinase domain in complex with DP-6233

7TNH の概要

• エントリーDOI: 10.2210/pdb7tnh/pdb
• 分子名称: Macrophage colony-stimulating factor 1 receptor,Fibroblast growth factor receptor 1 chimera, SODIUM ION, CHLORIDE ION, ... (5 entities in total)
• 機能のキーワード: human csr1r kinase, cancer, transferase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 39083.07

構造登録者

Edwards, T.E.,Arakaki, T.L.,Chun, L.,Flynn, D.L. (登録日: 2022-01-21, 公開日: 2022-08-24, 最終更新日: 2023-10-18)

• 主引用文献: Caldwell, T.M.,Kaufman, M.D.,Wise, S.C.,Mi Ahn, Y.,Hood, M.M.,Lu, W.P.,Patt, W.C.,Samarakoon, T.,Vogeti, L.,Vogeti, S.,Yates, K.M.,Bulfer, S.L.,Le Bourdonnec, B.,Smith, B.D.,Flynn, D.L.; Discovery of acyl ureas as highly selective small molecule CSF1R kinase inhibitors.; Bioorg.Med.Chem.Lett., 74:128929-128929, 2022; PubMed: 35961461; DOI: 10.1016/j.bmcl.2022.128929

実験手法

X-RAY DIFFRACTION (2.7 Å)