7TLT

SARS-CoV-2 Spike-derived peptide S489-497 (YFPLQSYGF) presented by HLA-A*29:02

Summary for 7TLT

• Entry DOI: 10.2210/pdb7tlt/pdb
• Descriptor: HLA class I histocompatibility antigen, A alpha chain, Beta-2-microglobulin, Spike protein S1 peptide, ... (7 entities in total)
• Functional Keywords: human leukocyte antigen, major histocompatibility complex, hla-a29, hla-a*29:02, sars-cov-2, spike, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 108353.44

Authors

Murdolo, L.D.,Szeto, C.,Gras, S. (deposition date: 2022-01-18, release date: 2022-10-12, Last modification date: 2024-10-23)

Primary citation

Swaminathan, S.,Lineburg, K.E.,Panikkar, A.,Raju, J.,Murdolo, L.D.,Szeto, C.,Crooks, P.,Le Texier, L.,Rehan, S.,Dewar-Oldis, M.J.,Barnard, P.J.,Ambalathingal, G.R.,Neller, M.A.,Short, K.R.,Gras, S.,Khanna, R.,Smith, C.
Ablation of CD8 + T cell recognition of an immunodominant epitope in SARS-CoV-2 Omicron variants BA.1, BA.2 and BA.3.
Nat Commun, 13:6387-6387, 2022

PubMed Abstract: The emergence of the SARS-CoV-2 Omicron variant has raised concerns of escape from vaccine-induced immunity. A number of studies have demonstrated a reduction in antibody-mediated neutralization of the Omicron variant in vaccinated individuals. Preliminary observations have suggested that T cells are less likely to be affected by changes in Omicron. However, the complexity of human leukocyte antigen genetics and its impact upon immunodominant T cell epitope selection suggests that the maintenance of T cell immunity may not be universal. In this study, we describe the impact that changes in Omicron BA.1, BA.2 and BA.3 have on recognition by spike-specific T cells. These T cells constitute the immunodominant CD8 T cell response in HLA-A*29:02 COVID-19 convalescent and vaccinated individuals; however, they fail to recognize the Omicron-encoded sequence. These observations demonstrate that in addition to evasion of antibody-mediated immunity, changes in Omicron variants can also lead to evasion of recognition by immunodominant T cell responses.

PubMed: 36302758
DOI: 10.1038/s41467-022-34180-1

Experimental method

X-RAY DIFFRACTION (2.3 Å)