7TLE
Crystal Structure of small molecule beta-lactone 1 covalently bound to K-Ras(G12S)
Summary for 7TLE
Entry DOI | 10.2210/pdb7tle/pdb |
Descriptor | GTPase KRas, MAGNESIUM ION, (3R,4R)-1-[7-(8-chloronaphthalen-1-yl)-2-{[(2S)-1-methylpyrrolidin-2-yl]methoxy}-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl]-3-hydroxypiperidine-4-carbaldehyde, ... (6 entities in total) |
Functional Keywords | ras, oncoprotein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 20379.30 |
Authors | Ziyang, Z.,Guiley, K.Z.,Shokat, K.M. (deposition date: 2022-01-18, release date: 2022-08-03, Last modification date: 2023-10-18) |
Primary citation | Zhang, Z.,Guiley, K.Z.,Shokat, K.M. Chemical acylation of an acquired serine suppresses oncogenic signaling of K-Ras(G12S). Nat.Chem.Biol., 18:1177-1183, 2022 Cited by PubMed: 35864332DOI: 10.1038/s41589-022-01065-9 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.98716752773 Å) |
Structure validation
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