7TL8

1.95A resolution structure of independent phosphoglycerate mutase from S. aureus in complex with a macrocyclic peptide inhibitor (Sa-D3)

7TL8 の概要

• エントリーDOI: 10.2210/pdb7tl8/pdb
• 関連するBIRD辞書のPRD_ID: PRD_002492
• 分子名称: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase, Peptide Sa-D3, MANGANESE (II) ION, ... (4 entities in total)
• 機能のキーワード: phosphoglycerate mutase, ipglycermide, macrocyclic peptide inhibitors, metal ion binding, isomerase, isomerase-inhibitor complex, isomerase/inhibitor
• 由来する生物種: Staphylococcus aureus; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 59236.56

構造登録者

Liu, L.,Lovell, S.,Battaile, K.P.,Dranchak, P.,Queme, B.,Aitha, M.,van Neer, R.H.P.,Kimura, H.,Katho, T.,Suga, H.,Inglese, J. (登録日: 2022-01-18, 公開日: 2022-08-10, 最終更新日: 2023-10-18)

• 主引用文献: van Neer, R.H.P.,Dranchak, P.K.,Liu, L.,Aitha, M.,Queme, B.,Kimura, H.,Katoh, T.,Battaile, K.P.,Lovell, S.,Inglese, J.,Suga, H.; Serum-Stable and Selective Backbone-N-Methylated Cyclic Peptides That Inhibit Prokaryotic Glycolytic Mutases.; Acs Chem.Biol., 17:2284-2295, 2022; PubMed: 35904259; DOI: 10.1021/acschembio.2c00403

実験手法

X-RAY DIFFRACTION (1.95 Å)