7THV

Structure of the yeast clamp loader (Replication Factor C RFC) bound to the sliding clamp (Proliferating Cell Nuclear Antigen PCNA) in an autoinhibited conformation

Summary for 7THV

• Entry DOI: 10.2210/pdb7thv/pdb
• EMDB information: 25614
• Descriptor: Replication factor C subunit 1, Replication factor C subunit 4, Replication factor C subunit 3, ... (9 entities in total)
• Functional Keywords: sliding clamp, dna replication, aaa+, clamp loader, replication
• Biological source: Saccharomyces cerevisiae (baker's yeast); More
• Total number of polymer chains: 8
• Total formula weight: 340486.38

Authors

Gaubitz, C.,Liu, X.,Pajak, J.,Stone, N.,Hayes, J.,Demo, G.,Kelch, B.A. (deposition date: 2022-01-12, release date: 2022-02-16, Last modification date: 2024-02-28)

• Primary citation: Gaubitz, C.,Liu, X.,Pajak, J.,Stone, N.P.,Hayes, J.A.,Demo, G.,Kelch PhD, B.A.; Cryo-EM structures reveal high-resolution mechanism of a DNA polymerase sliding clamp loader.; Elife, 11:-, 2022; PubMed: 35179493; DOI: 10.7554/eLife.74175

Experimental method

ELECTRON MICROSCOPY (4 Å)