7TFP
Human Ornithine Aminotransferase cocrystallized with its inhibitor, (1S,3S)-3-amino-4-(difluoromethylene)cyclopentane-1-carboxylic acid.
7TFP の概要
エントリーDOI | 10.2210/pdb7tfp/pdb |
分子名称 | Ornithine aminotransferase, mitochondrial, PYRIDOXAL-5'-PHOSPHATE, (1S,3S,4S)-3-amino-4-(fluoromethyl)cyclopentane-1-carboxylic acid, ... (4 entities in total) |
機能のキーワード | human ornithine aminotransferase, hoat, oat, mechanism-based inhibitor, mbi, irreversible inhibitor, inactivator, transferase |
由来する生物種 | Homo sapiens (human) |
タンパク質・核酸の鎖数 | 3 |
化学式量合計 | 135483.56 |
構造登録者 | |
主引用文献 | Zhu, W.,Butrin, A.,Melani, R.D.,Doubleday, P.F.,Ferreira, G.M.,Tavares, M.T.,Habeeb Mohammad, T.S.,Beaupre, B.A.,Kelleher, N.L.,Moran, G.R.,Liu, D.,Silverman, R.B. Rational Design, Synthesis, and Mechanism of (3 S ,4 R )-3-Amino-4-(difluoromethyl)cyclopent-1-ene-1-carboxylic Acid: Employing a Second-Deprotonation Strategy for Selectivity of Human Ornithine Aminotransferase over GABA Aminotransferase. J.Am.Chem.Soc., 144:5629-5642, 2022 Cited by PubMed: 35293728DOI: 10.1021/jacs.2c00924 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.71 Å) |
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