7TFN

Cryo-EM structure of CD4bs antibody Ab1303 in complex with HIV-1 Env trimer BG505 SOSIP.664

7TFN の概要

• エントリーDOI: 10.2210/pdb7tfn/pdb
• EMDBエントリー: 25877
• 分子名称: Envelope glycoprotein BG505 SOSIP.664 - gp120, 2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose, ... (11 entities in total)
• 機能のキーワード: hiv-1 env, neutralizing antibody, cd4 binding site antibody, viral protein, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Human immunodeficiency virus 1; 詳細
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 371403.56

構造登録者

Yang, Z.,Bjorkman, P.J. (登録日: 2022-01-06, 公開日: 2022-01-19, 最終更新日: 2022-02-23)

• 主引用文献: Yang, Z.,Dam, K.A.,Bridges, M.D.,Hoffmann, M.A.G.,DeLaitsch, A.T.,Gristick, H.B.,Escolano, A.,Gautam, R.,Martin, M.A.,Nussenzweig, M.C.,Hubbell, W.L.,Bjorkman, P.J.; Neutralizing antibodies induced in immunized macaques recognize the CD4-binding site on an occluded-open HIV-1 envelope trimer.; Nat Commun, 13:732-732, 2022; PubMed: 35136084; DOI: 10.1038/s41467-022-28424-3

実験手法

ELECTRON MICROSCOPY (4 Å)