7TDC

Crystal structure of the E. coli thiM riboswitch in complex with thiamine bisphosphonate, calcium ions

Summary for 7TDC

Entry DOI	10.2210/pdb7tdc/pdb
Descriptor	thiM riboswitch RNA (83-MER), [2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-5-yl]ethoxy-oxidanyl-phosphoryl]methylphosphonic acid, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	rna
Biological source	Escherichia coli
Total number of polymer chains	1
Total formula weight	27421.54
Authors	Nuthanakanti, A.,Serganov, A. (deposition date: 2021-12-30, release date: 2022-02-16, Last modification date: 2023-10-18)
Primary citation	Zeller, M.J.,Nuthanakanti, A.,Li, K.,Aube, J.,Serganov, A.,Weeks, K.M. Subsite Ligand Recognition and Cooperativity in the TPP Riboswitch: Implications for Fragment-Linking in RNA Ligand Discovery. Acs Chem.Biol., 17:438-448, 2022 Cited by PubMed: 35060698 DOI: 10.1021/acschembio.1c00880 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.46 Å)

Structure validation