7TCZ
Human cytomegalovirus protease mutant (C84A, C87A, C138A, C202A) in complex with inhibitor
Summary for 7TCZ
Entry DOI | 10.2210/pdb7tcz/pdb |
Descriptor | Assemblin, [1-(2-oxopropyl)-4-phenyl-1H-1,2,3-triazol-5-yl]methyl benzylcarbamate (3 entities in total) |
Functional Keywords | protease, viral protein, hyrdrolase-hydrolase inhibitor complex, hyrdrolase/hydrolase inhibitor |
Biological source | Human betaherpesvirus 5 |
Total number of polymer chains | 1 |
Total formula weight | 29325.81 |
Authors | Hulce, K.R.,Bohn, M.,Ongpipattanakul, C.,Jaishankar, P.,Renslo, A.R.,Craik, C.S. (deposition date: 2021-12-29, release date: 2022-01-12, Last modification date: 2023-10-18) |
Primary citation | Hulce, K.R.,Jaishankar, P.,Lee, G.M.,Bohn, M.F.,Connelly, E.J.,Wucherer, K.,Ongpipattanakul, C.,Volk, R.F.,Chuo, S.W.,Arkin, M.R.,Renslo, A.R.,Craik, C.S. Inhibiting a dynamic viral protease by targeting a non-catalytic cysteine. Cell Chem Biol, 29:785-798.e19, 2022 Cited by PubMed: 35364007DOI: 10.1016/j.chembiol.2022.03.007 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.67 Å) |
Structure validation
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