7TCI

Structure of Xenopus KCNQ1-CaM in complex with ML277

7TCI の概要

• エントリーDOI: 10.2210/pdb7tci/pdb
• EMDBエントリー: 25813 25816
• 分子名称: Potassium voltage-gated channel subfamily KQT member 1, Calmodulin-1, (2R)-N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-1-(4-methylbenzene-1-sulfonyl)piperidine-2-carboxamide, ... (4 entities in total)
• 機能のキーワード: activator, ion channel, transport protein-activator complex, transport protein/activator
• 由来する生物種: Xenopus laevis (African clawed frog); 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 320431.08

構造登録者

Willegems, K.,Kyriakis, E.,Van Petegem, F.,Eldstrom, J.,Fedida, D. (登録日: 2021-12-23, 公開日: 2022-07-06, 最終更新日: 2024-02-28)

• 主引用文献: Willegems, K.,Eldstrom, J.,Kyriakis, E.,Ataei, F.,Sahakyan, H.,Dou, Y.,Russo, S.,Van Petegem, F.,Fedida, D.; Structural and electrophysiological basis for the modulation of KCNQ1 channel currents by ML277.; Nat Commun, 13:3760-3760, 2022; PubMed: 35768468; DOI: 10.1038/s41467-022-31526-7

実験手法

ELECTRON MICROSCOPY (3.9 Å)