7TC1
Crystal structure of D179N KPC-2 beta-lactamase in complex with vaborbactam
Summary for 7TC1
Entry DOI | 10.2210/pdb7tc1/pdb |
Related | 7TB7 |
Descriptor | Carbapenem-hydrolyzing beta-lactamase KPC, Vaborbactam, PHOSPHATE ION, ... (4 entities in total) |
Functional Keywords | beta-lactamase, antibiotic resistance, hydrolase |
Biological source | Klebsiella pneumoniae |
Total number of polymer chains | 1 |
Total formula weight | 28567.86 |
Authors | van den Akker, F.,Alsenani, T. (deposition date: 2021-12-22, release date: 2022-03-02, Last modification date: 2023-10-18) |
Primary citation | Alsenani, T.A.,Viviani, S.L.,Kumar, V.,Taracila, M.A.,Bethel, C.R.,Barnes, M.D.,Papp-Wallace, K.M.,Shields, R.K.,Nguyen, M.H.,Clancy, C.J.,Bonomo, R.A.,van den Akker, F. Structural Characterization of the D179N and D179Y Variants of KPC-2 beta-Lactamase: Omega-Loop Destabilization as a Mechanism of Resistance to Ceftazidime-Avibactam. Antimicrob.Agents Chemother., 66:e0241421-e0241421, 2022 Cited by PubMed: 35341315DOI: 10.1128/aac.02414-21 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.16 Å) |
Structure validation
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