7T9V
Crystal structure of hSTING with the agonist, SHR171032
Summary for 7T9V
Entry DOI | 10.2210/pdb7t9v/pdb |
Descriptor | Stimulator of interferon genes protein, CALCIUM ION, (3S,4S)-4-(3-{5-carbamoyl-2-[(1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)amino]-7-methoxy-1H-benzimidazol-1-yl}propyl)-2-[(1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)amino]-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazine-8-carboxamide, ... (4 entities in total) |
Functional Keywords | agonist, immune system, immune system-inhibitor complex, immune system-agonist complex, immune system/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 46023.67 |
Authors | Chowdhury, R.,Miller, M. (deposition date: 2021-12-20, release date: 2022-12-21, Last modification date: 2023-10-25) |
Primary citation | Song, C.,Liu, D.,Liu, S.,Li, D.,Horecny, I.,Zhang, X.,Li, P.,Chen, L.,Miller, M.,Chowdhury, R.,Issa, M.,Shen, R.,Yan, Y.,Zhang, F.,Zhang, L.,Zhang, L.,Bai, C.,Feng, J.,Zhuang, L.,Zhang, R.,Li, J.,Wilkinson, H.,Liu, J.,Tao, W. SHR1032, a novel STING agonist, stimulates anti-tumor immunity and directly induces AML apoptosis. Sci Rep, 12:8579-8579, 2022 Cited by PubMed: 35595822DOI: 10.1038/s41598-022-12449-1 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.68 Å) |
Structure validation
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