7T8R

Co-crystal structure of SARS-CoV-2 Mpro C145A with substrate peptide 7/8

Summary for 7T8R

Entry DOI	10.2210/pdb7t8r/pdb
Descriptor	3C-like proteinase, Nonstructural protein 7/8, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	coronavirus, covid-19, covid, protease, drug resistance, complex, hydrolase, durg discovery, main protease, mpro, substrate complex, nsp 4/5, viral protein
Biological source	Severe acute respiratory syndrome coronavirus 2 More
Total number of polymer chains	2
Total formula weight	35145.00
Authors	Shaqra, A.M.,Schiffer, C.A. (deposition date: 2021-12-16, release date: 2022-06-22, Last modification date: 2023-10-18)
Primary citation	Shaqra, A.M.,Zvornicanin, S.N.,Huang, Q.Y.J.,Lockbaum, G.J.,Knapp, M.,Tandeske, L.,Bakan, D.T.,Flynn, J.,Bolon, D.N.A.,Moquin, S.,Dovala, D.,Kurt Yilmaz, N.,Schiffer, C.A. Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance. Nat Commun, 13:3556-3556, 2022 Cited by PubMed: 35729165 DOI: 10.1038/s41467-022-31210-w PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.74 Å)

Structure validation