7T8G

G93A mutant of human SOD1 bound with MR6-8-2 in P21 space group

Summary for 7T8G

Entry DOI	10.2210/pdb7t8g/pdb
Descriptor	Superoxide dismutase [Cu-Zn], ZINC ION, ~{N}-(pyridin-3-ylmethyl)-2-selanyl-benzamide, ... (7 entities in total)
Functional Keywords	sod1, als, drug discovery, oxidoreductase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	32857.35
Authors	Amporndanai, K.,Hasnain, S.S. (deposition date: 2021-12-16, release date: 2023-01-25, Last modification date: 2024-06-05)
Primary citation	Watanabe, S.,Amporndanai, K.,Awais, R.,Latham, C.,Awais, M.,O'Neill, P.M.,Yamanaka, K.,Hasnain, S.S. Ebselen analogues delay disease onset and its course in fALS by on-target SOD-1 engagement. Sci Rep, 14:12118-12118, 2024 Cited by PubMed: 38802492 DOI: 10.1038/s41598-024-62903-5 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.35 Å)

Structure validation