7T7S
R-27 in Complex with S. aureus DHFR and tricyclic-NADPH (tNADPH)
Summary for 7T7S
| Entry DOI | 10.2210/pdb7t7s/pdb |
| Descriptor | Dihydrofolate reductase, Tricyclic NADPH, 6-ethyl-5-{(3R)-3-[3-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1-yl}pyrimidine-2,4-diamine, ... (5 entities in total) |
| Functional Keywords | dhfr, cofactor, antibiotic resistance, antifolates, oxidoreductase |
| Biological source | Staphylococcus aureus |
| Total number of polymer chains | 1 |
| Total formula weight | 19193.47 |
| Authors | Reeve, S.M.,Wang, S.,Donald, B.R.,Wright, D.L. (deposition date: 2021-12-15, release date: 2022-02-02, Last modification date: 2023-10-18) |
| Primary citation | Wang, S.,Reeve, S.M.,Holt, G.T.,Ojewole, A.A.,Frenkel, M.S.,Gainza, P.,Keshipeddy, S.,Fowler, V.G.,Wright, D.L.,Donald, B.R. Chiral evasion and stereospecific antifolate resistance in Staphylococcus aureus. Plos Comput.Biol., 18:e1009855-e1009855, 2022 Cited by PubMed: 35143481DOI: 10.1371/journal.pcbi.1009855 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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