7T7M
Structure of human GLP SET-domain (EHMT1) in complex with covalent inhibitor (Compound 1)
Summary for 7T7M
Entry DOI | 10.2210/pdb7t7m/pdb |
Descriptor | Histone-lysine N-methyltransferase EHMT1, ZINC ION, N-(6-methoxy-4-{[1-(propan-2-yl)piperidin-4-yl]amino}-7-[3-(pyrrolidin-1-yl)propoxy]quinazolin-2-yl)prop-2-enamide, ... (5 entities in total) |
Functional Keywords | glp, covalent inhibitor, gene regulation, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 134932.52 |
Authors | Park, K.-S.,Kumar, P. (deposition date: 2021-12-15, release date: 2022-07-06, Last modification date: 2023-10-18) |
Primary citation | Park, K.S.,Xiong, Y.,Yim, H.,Velez, J.,Babault, N.,Kumar, P.,Liu, J.,Jin, J. Discovery of the First-in-Class G9a/GLP Covalent Inhibitors. J.Med.Chem., 65:10506-10522, 2022 Cited by PubMed: 35763668DOI: 10.1021/acs.jmedchem.2c00652 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.85 Å) |
Structure validation
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