7T6G

Truncated Ac-AIP-2

Summary for 7T6G

• Entry DOI: 10.2210/pdb7t6g/pdb
• NMR Information: BMRB: 30975
• Descriptor: Truncated Ac-AIP-2 (1 entity in total)
• Functional Keywords: anti-inflammatory activity, unknown function
• Biological source: Ancylostoma caninum
• Total number of polymer chains: 1
• Total formula weight: 2301.57

Authors

Daly, N.L.,Cobos, C. (deposition date: 2021-12-13, release date: 2022-10-19, Last modification date: 2024-05-15)

Primary citation

Cobos, C.,Bansal, P.S.,Wilson, D.T.,Jones, L.,Zhao, G.,Field, M.A.,Eichenberger, R.M.,Pickering, D.A.,Ryan, R.Y.M.,Ratnatunga, C.N.,Miles, J.J.,Ruscher, R.,Giacomin, P.R.,Navarro, S.,Loukas, A.,Daly, N.L.
Peptides derived from hookworm anti-inflammatory proteins suppress inducible colitis in mice and inflammatory cytokine production by human cells.
Front Med (Lausanne), 9:934852-934852, 2022

PubMed Abstract: A decline in the prevalence of parasites such as hookworms appears to be correlated with the rise in non-communicable inflammatory conditions in people from high- and middle-income countries. This correlation has led to studies that have identified proteins produced by hookworms that can suppress inflammatory bowel disease (IBD) and asthma in animal models. Hookworms secrete a family of abundant netrin-domain containing proteins referred to as AIPs (Anti-Inflammatory Proteins), but there is no information on the structure-function relationships. Here we have applied a downsizing approach to the hookworm AIPs to derive peptides of 20 residues or less, some of which display anti-inflammatory effects when co-cultured with human peripheral blood mononuclear cells and oral therapeutic activity in a chemically induced mouse model of acute colitis. Our results indicate that a conserved helical region is responsible, at least in part, for the anti-inflammatory effects. This helical region has potential in the design of improved leads for treating IBD and possibly other inflammatory conditions.

PubMed: 36186812
DOI: 10.3389/fmed.2022.934852

Experimental method

SOLUTION NMR