7T5X

P. aeruginosa LpxA in complex with ligand L6

Summary for 7T5X

• Entry DOI: 10.2210/pdb7t5x/pdb
• Descriptor: Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase, Nalpha-(tert-butoxycarbonyl)-N-1H-tetrazol-5-yl-D-tryptophanamide (3 entities in total)
• Functional Keywords: lpxa, lipid a, lps, lipopolysaccharide, udp-n-acetylglucosamine o-acyltransferase, transferase
• Biological source: Pseudomonas aeruginosa PA7
• Total number of polymer chains: 6
• Total formula weight: 170520.74

Authors

Sacco, M.,Chen, Y. (deposition date: 2021-12-13, release date: 2022-07-06, Last modification date: 2023-10-18)

• Primary citation: Sacco, M.D.,Defrees, K.,Zhang, X.,Lawless, W.,Nwanochie, E.,Balsizer, A.,Darch, S.E.,Renslo, A.R.,Chen, Y.; Structure-Based Ligand Design Targeting Pseudomonas aeruginosa LpxA in Lipid A Biosynthesis.; Acs Infect Dis., 8:1231-1240, 2022; PubMed: 35653508; DOI: 10.1021/acsinfecdis.1c00650

Experimental method

X-RAY DIFFRACTION (2.2 Å)