7T4V

Crystal Structure of cGMP-dependent Protein Kinase

7T4V の概要

• エントリーDOI: 10.2210/pdb7t4v/pdb
• 分子名称: cGMP-dependent protein kinase 1, 4-({(2S,3S)-3-[(1S)-1-(3,5-dichlorophenyl)-2-hydroxyethoxy]-2-phenylpiperidin-1-yl}methyl)-3-methylbenzoic acid, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: cyclic nucleotide binding domains, cyclic nucleotide protein kinase, transferase, pkg, cgmp-dependent protein kinase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 107453.99

構造登録者

Zebisch, M.,Silvestre, L.,Fischmann, T.O. (登録日: 2021-12-10, 公開日: 2023-06-14, 最終更新日: 2023-07-12)

• 主引用文献: Metwally, E.,Mak, V.,Sylvestre, H.L.,McEwan, P.,Baker, J.J.,Rose, Y.,Patel, A.,Lim, Y.-H.,Healy, D.,Hanisak, J.,Ermakov, G.,Beaumont, M.,Cheng, A.C.,Greshock, T.,Fischmann, T.O.; Selective small molecule activation of PKG1alpha: structure and function; Commun Biol, 2023

実験手法

X-RAY DIFFRACTION (2.28 Å)