7T3V
Metal dependent activation of Plasmodium falciparum M17 aminopeptidase, spacegroup P22121 after crystals soaked with Zn2+
Summary for 7T3V
Entry DOI | 10.2210/pdb7t3v/pdb |
Descriptor | M17 leucyl aminopeptidase, CARBONATE ION, ZINC ION, ... (6 entities in total) |
Functional Keywords | metallo aminopeptidase, malaria, peptide binding protein, hydrolase |
Biological source | Plasmodium falciparum (malaria parasite P. falciparum) |
Total number of polymer chains | 6 |
Total formula weight | 353040.10 |
Authors | Webb, C.T.,McGowan, S. (deposition date: 2021-12-08, release date: 2022-06-29, Last modification date: 2023-10-18) |
Primary citation | Webb, C.T.,Yang, W.,Riley, B.T.,Hayes, B.K.,Sivaraman, K.K.,Malcolm, T.R.,Harrop, S.,Atkinson, S.C.,Kass, I.,Buckle, A.M.,Drinkwater, N.,McGowan, S. A metal ion-dependent conformational switch modulates activity of the Plasmodium M17 aminopeptidase. J.Biol.Chem., 298:102119-102119, 2022 Cited by PubMed: 35691342DOI: 10.1016/j.jbc.2022.102119 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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