7T3F
Development of BRD4 inhibitors as arsenicals antidotes
Summary for 7T3F
Entry DOI | 10.2210/pdb7t3f/pdb |
Descriptor | Bromodomain-containing protein 4, 4-fluoro-3-methyl-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzene-1-sulfonamide, GLYCEROL, ... (4 entities in total) |
Functional Keywords | bromodomain-containing protein, dna damage, antidotes, brd4 inhibitors, gene regulation |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 15704.05 |
Authors | Wu, M.,Yatchang, M.,Mathew, B.,Zhai, L.,Ruiz, P.,Bostwick, R.,Augelli-Szafran, C.E.,Suto, M.J. (deposition date: 2021-12-07, release date: 2022-08-31, Last modification date: 2023-10-18) |
Primary citation | Yatchang, M.F.,Mathew, B.,Srivastava, R.K.,Khan, J.,Muzaffar, S.,Zhang, S.,Wu, M.,Zhai, L.,Ruiz, P.,Agarwal, A.,Bostwick, J.R.,Suto, M.J.,Athar, M.,Augelli-Szafran, C.E. Development of BRD4 inhibitors as anti-inflammatory agents and antidotes for arsenicals. Bioorg.Med.Chem.Lett., 64:128696-128696, 2022 Cited by PubMed: 35318165DOI: 10.1016/j.bmcl.2022.128696 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.28 Å) |
Structure validation
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