7T3F

Development of BRD4 inhibitors as arsenicals antidotes

7T3F の概要

• エントリーDOI: 10.2210/pdb7t3f/pdb
• 分子名称: Bromodomain-containing protein 4, 4-fluoro-3-methyl-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzene-1-sulfonamide, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: bromodomain-containing protein, dna damage, antidotes, brd4 inhibitors, gene regulation
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15704.05

構造登録者

Wu, M.,Yatchang, M.,Mathew, B.,Zhai, L.,Ruiz, P.,Bostwick, R.,Augelli-Szafran, C.E.,Suto, M.J. (登録日: 2021-12-07, 公開日: 2022-08-31, 最終更新日: 2023-10-18)

• 主引用文献: Yatchang, M.F.,Mathew, B.,Srivastava, R.K.,Khan, J.,Muzaffar, S.,Zhang, S.,Wu, M.,Zhai, L.,Ruiz, P.,Agarwal, A.,Bostwick, J.R.,Suto, M.J.,Athar, M.,Augelli-Szafran, C.E.; Development of BRD4 inhibitors as anti-inflammatory agents and antidotes for arsenicals.; Bioorg.Med.Chem.Lett., 64:128696-128696, 2022; PubMed: 35318165; DOI: 10.1016/j.bmcl.2022.128696

実験手法

X-RAY DIFFRACTION (1.28 Å)