7T2B

Crystal structure of the 5F TCR in complex with HLA-DP4-Ply

7T2B の概要

• エントリーDOI: 10.2210/pdb7t2b/pdb
• 分子名称: HLA class II histocompatibility antigen, DP alpha 1 chain, HLA class II histocompatibility antigen, DP beta 1 chain, Pneumolysin-derived peptide, ... (9 entities in total)
• 機能のキーワード: tcr-phla complex, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 20
• 化学式量合計: 382319.20

構造登録者

Ciacchi, L.,Farenc, C.,Petersen, J.,Reid, H.H.,Rossjohn, J. (登録日: 2021-12-03, 公開日: 2022-12-28, 最終更新日: 2023-10-25)

• 主引用文献: Ciacchi, L.,van de Garde, M.D.B.,Ladell, K.,Farenc, C.,Poelen, M.C.M.,Miners, K.L.,Llerena, C.,Reid, H.H.,Petersen, J.,Price, D.A.,Rossjohn, J.,van Els, C.A.C.M.; CD4 + T cell-mediated recognition of a conserved cholesterol-dependent cytolysin epitope generates broad antibacterial immunity.; Immunity, 56:1082-1097.e6, 2023; PubMed: 37100059; DOI: 10.1016/j.immuni.2023.03.020

実験手法

X-RAY DIFFRACTION (2.8 Å)