7T0P

JAK2 JH2 IN COMPLEX WITH JAK315

Summary for 7T0P

• Entry DOI: 10.2210/pdb7t0p/pdb
• Descriptor: Tyrosine-protein kinase JAK2, 4'-{[5-amino-3-(4-sulfamoylanilino)-1H-1,2,4-triazole-1-carbonyl]amino}-4-(benzyloxy)[1,1'-biphenyl]-3-carboxylic acid, GLYCEROL, ... (4 entities in total)
• Functional Keywords: pseudokinase domain, inhibitor, complex, transferase, transferase-transferase inhibitor complex, signaling protein, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 67625.34

Authors

Ippolito, J.A.,Liosi, M.-E.,Krimmer, S.G.,Schlessinger, J.,Jorgensen, W.L. (deposition date: 2021-11-30, release date: 2022-06-15, Last modification date: 2023-10-18)

• Primary citation: Liosi, M.E.,Ippolito, J.A.,Henry, S.P.,Krimmer, S.G.,Newton, A.S.,Cutrona, K.J.,Olivarez, R.A.,Mohanty, J.,Schlessinger, J.,Jorgensen, W.L.; Insights on JAK2 Modulation by Potent, Selective, and Cell-Permeable Pseudokinase-Domain Ligands.; J.Med.Chem., 65:8380-8400, 2022; PubMed: 35653642; DOI: 10.1021/acs.jmedchem.2c00283

Experimental method

X-RAY DIFFRACTION (2.04 Å)