7T0P

JAK2 JH2 IN COMPLEX WITH JAK315

7T0P の概要

• エントリーDOI: 10.2210/pdb7t0p/pdb
• 分子名称: Tyrosine-protein kinase JAK2, 4'-{[5-amino-3-(4-sulfamoylanilino)-1H-1,2,4-triazole-1-carbonyl]amino}-4-(benzyloxy)[1,1'-biphenyl]-3-carboxylic acid, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: pseudokinase domain, inhibitor, complex, transferase, transferase-transferase inhibitor complex, signaling protein, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 67625.34

構造登録者

Ippolito, J.A.,Liosi, M.-E.,Krimmer, S.G.,Schlessinger, J.,Jorgensen, W.L. (登録日: 2021-11-30, 公開日: 2022-06-15, 最終更新日: 2023-10-18)

• 主引用文献: Liosi, M.E.,Ippolito, J.A.,Henry, S.P.,Krimmer, S.G.,Newton, A.S.,Cutrona, K.J.,Olivarez, R.A.,Mohanty, J.,Schlessinger, J.,Jorgensen, W.L.; Insights on JAK2 Modulation by Potent, Selective, and Cell-Permeable Pseudokinase-Domain Ligands.; J.Med.Chem., 65:8380-8400, 2022; PubMed: 35653642; DOI: 10.1021/acs.jmedchem.2c00283

実験手法

X-RAY DIFFRACTION (2.04 Å)